Diindolylmethane (DIM)

Chemical Formula	C17H14N2
Molecular Weight	246.313 g/mol
Names and Identifiers	PubChem Link
Traditional Name	Diindolylmethane (DIM), 3,3'-Diindolylmethane
CAS Registry Number	1968-05-4

 

3,3′-Diindolylmethane (DIM) is a compound derived from the digestion of indole-3-carbinol, found in cruciferous vegetables such as broccoli, Brussels sprouts, cabbage and kale. The reputation of Brassica vegetables as healthy foods rests in part on the activities of diindolylmethane.

Clinical data for the effects of DIM are limited, but because of potential anticancer properties, the National Cancer Institute of the United States has begun clinical trials of DIM as a therapeutic for numerous forms of cancer. Much of the scientific interest is due to its action as a histone deacetylase inhibitor in vitro, specifically against HDAC1, HDAC2, and HDAC3.

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