Immune system is body’s defense against infections and other harmful invaders. The immune system is made up of special cells, tissues, and organs that work together to protect the body.
The lymphatic system is a major part of the immune system. The lymphatic system is a network of lymph nodes and lymphatic vessels. Lymphatic vessels are thin tubes that go throughout the body and carry a clear fluid called lymph. Lymph contains tissue fluids, immune system cells, and waste products. Lymph nodes are small bean-shaped clumps of immune system cells, which are connected by lymphatic vessels. Lymph nodes contain white blood cells. White blood cells are the cells of the immune system, which are made in bone marrow, the one of lymph organs. Other lymph organs are the spleen and thymus. White blood cells trap the viruses, bacteria, and other invaders, also including cancer cells. When the immune system does not function properly the complications may arise, such as immune deficiencies, overactive response, and autoimmune diseases.
Severe combined immunodeficiency (SCID) — immune deficiency that is present since birth.
Temporary acquired immune deficiencies – weakening of the immune system, which may be caused by many factors, such as drugs, smoking, alcohol, poor nutrition, environmental toxins.
HIV viral infection may destroy important white blood cells and weaken the immune system.
Overactive immune system:
Allergies — certain genes may provoke the immune system to recognize harmless substances as allergens and react to it. Allergic reaction is the most common example of an overactive immune system.
Asthma — the response in the lungs which can cause coughing, wheezing, and difficulties to breathe.
Eczema – happens when an allergen causes an itchy rash (atopic dermatitis).
Allergic rhinitis — a runny nose, sneezing, sniffling, and swelling of the nasal passages from indoor or outdoor allergens.
An autoimmune diseases is when the body’s immune system attacks normal and healthy tissues. The cause of autoimmune diseases is still not well identified. Probably, it is a combination of a person’s genes and environmental triggers. Three common autoimmune diseases are:
Type 1 diabetes – it is when the immune system attacks the cells in the pancreas that producing insulin.
Rheumatoid arthritis — this is a type of arthritis, which is causing swelling and deformities of the joints.
Lupus – it is when the immune system attacks body tissues, including the skin, lungs, and kidneys.
Publications and factsheets
Disorders of the Immune System 
Autoinflammatory Diseases (National Institute of Arthritis and Musculoskeletal and Skin Diseases) 
About Primary Immunodeficiencies (The Immune Deficiency Foundation) 
- www.hopkinsmedicine.org | disorders of the immune system
- www.niams.nih.gov | autoinflammatory diseases
- primaryimmune.org | about primary immunodeficiencies
- icd.who.int | 10/2016
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