Quercetin

Quercetin and Vitamin C: An Experimental, Synergistic Therapy for the Prevention and Treatment of SARS-CoV-2 Related Disease (COVID-19)
Quercetin and Vitamin C: An Experimental, Synergistic Therapy for the Prevention and Treatment of SARS-CoV-2 Related Disease (COVID-19)
Quercetin displays a broad range of antiviral properties which can interfere at multiple steps of pathogen virulence -virus entry, virus replication, protein assembly- and that these therapeutic effects can be augmented by the co-administration of vitamin C. Furthermore, due to their lack of severe side effects and low-costs, we strongly suggest the combined administration of these two compounds for both the prophylaxis and the early treatment of respiratory tract infections, especially including COVID-19 patients.
Current Updates on Naturally Occurring Compounds Recognizing SARS-CoV-2 Druggable Targets
Current Updates on Naturally Occurring Compounds Recognizing SARS-CoV-2 Druggable Targets
Quercetin is a flavonol abundantly present in vegetables and fruits. This compound gained attention for its pharmacological properties, such as antiviral, anti-inflammatory, pro-metabolic and anticancer. In light of this, quercetin was studied against COVID-19 as well.
Anti-COVID-19 drug candidates: A review on potential biological activities of natural products in the management of new coronavirus infection
Anti-COVID-19 drug candidates: A review on potential biological activities of natural products in the management of new coronavirus infection
Several natural compounds have showed their promising actions on multiple therapeutic targets, which should be further explored. Among them, quercetin, one of the most abundant of plant flavonoids, is proposed as a lead candidate with its ability on the virus side to inhibit SARS-CoV spike protein-angiotensin-converting enzyme 2 (ACE2) interaction, viral protease and helicase activities, as well as on the host cell side to inhibit ACE activity and increase intracellular zinc level.
Perspectives on plant flavonoid quercetin based drugs for novel SARS-CoV-2
Perspectives on plant flavonoid quercetin based drugs for novel SARS-CoV-2
Earlier studies which have established the antiviral activities of quercetin shall pave way to develop effective, safe, and affordable natural formulations for the treatment and prophylaxis of novel coronavirus. This review has mainly focused on the perspective of developing quercetin-based SARS-CoV2 drugs, based on its ability to inhibit the key enzymes of the virus.
Quercetin: Antiviral Significance and Possible COVID-19 Integrative Considerations
Quercetin: Antiviral Significance and Possible COVID-19 Integrative Considerations
Quercetin could be a therapeutic tool to be assayed against COVID-19, either alone or in combination with other nutritional substances, antivirals, or other drugs. Quercetin may affect medications metabolized by CYP2C8, CYP2D6, CYP3A4, and P-glycoprotein substrates, and this is a concern for its use that has to be taken into consideration. As Quercetin can inhibit coronavirus enzymes, which are essential for virus replication and infection, therefore it provides a potential key for designing antiviral therapies for inhibiting viral proteases.
Quercetin Phytosome® as a potential drug for Covid-19
Quercetin Phytosome® as a potential drug for Covid-19
A phospholipid complex of quercetin (Quercetin Phytosome®) has been recently tested in humans to evaluate a possible improvement in oral bioavailability. After hydrolysis of the conjugated form (mainly glucuronide) of quercetin found in human plasma, the pharmacokinetics results have demonstrated an increased bioavailability rate by about 20-fold for total quercetin. It has been also observed that the presence of specific glucuronidase could yield free systemic quercetin in human body. Taking also into considerations its anti-inflammatory and thrombin-inhibitory actions, a bioavailable form of quercetin, like Quercetin Phytosome®, should be considered a possible candidate to clinically face COVID-19.
Quercetin as a potential treatment for COVID-19-induced acute kidney injury: Based on network pharmacology and molecular docking study
Quercetin as a potential treatment for COVID-19-induced acute kidney injury: Based on network pharmacology and molecular docking study
The renal protective effects of Quercetin on COVID-19-induced AKI may be associated with the blockade of the activation of inflammatory, cell apoptosis-related signaling pathways. Quercetin may also serve as SARS-CoV-2 inhibitor by binding with the active sites of SARS-CoV-2 main protease 3CL and ACE2, therefore suppressing the functions of the proteins to cut the viral life cycle.
Anti-inflammatory potential of Quercetin in COVID-19 treatment
Anti-inflammatory potential of Quercetin in COVID-19 treatment
Quercetin is a carbohydrate-free flavonoid that is the most abundant flavonoid in vegetables and fruits and has been the most studied to determine the biological effects of flavonoids. Inflammasomes are cytosolic multi-protein complexes assembling in response to cytosolic PAMP and DAMPs, whose function is to generate active forms of cytokines IL-1β and IL-18. Activation or inhibition of the NLRP3 inflammasome is affected by regulators such as TXNIP, SIRT1 and NRF2. Quercetin suppresses the NLRP3 inflammasome by affecting these regulators.
A role for quercetin in coronavirus disease 2019 (COVID-19)
A role for quercetin in coronavirus disease 2019 (COVID-19)
When looking for new antiviral compounds, knowledge of the main viral proteins is fundamental. The major druggable targets of SARS-CoV-2 include 3-chymotrypsin-like protease (3CLpro), papain-like protease (PLpro), RNA-dependent RNA polymerase, and spike (S) protein. Quercetin inhibits 3CLpro and PLpro with a docking binding energy corresponding to −6.25 and −4.62 kcal/mol, respectively. Quercetin has a theoretical, but significant, capability to interfere with SARS-CoV-2 replication.
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