ABSTRACT: Oral administration of NAC (600 mg/day) could function as a preventive measure, particularly in those repeatedly exposed to possible SARS-CoV-2 carriers (e.g., health workers). This application could be a particularly urgent approach since, despite the use of personal protective equipment, healthcare workers in the USA, Italy, China, Mexico, etc., have become infected while caring for hospitalized patient. Other workers who, due to their job requirements, cannot work at home and/or ensure self-isolation might also benefit from preventive use of NAC administration. If deemed effective, this latter use could potentially help to flatten the exponential contagion curve in several countries. More clinical trials would clearly be needed to validate this application.