The skin is one of the largest organs in the body in surface area and weight. The skin consists of two layers: the epidermis and the dermis. Beneath the dermis lies the hypodermis or subcutaneous fatty tissue. The skin has three main functions: protection, regulation and sensation. Wounding affects all the functions of the skin.
The primary function of the skin is to act as a barrier. The skin provides protection from: mechanical impacts and pressure, variations in temperature, micro-organisms, radiation and chemicals.
The skin regulates several aspects of physiology, including: body temperature via sweat and hair, and changes in peripheral circulation and fluid balance via sweat. It also acts as a reservoir for the synthesis of Vitamin D.
The skin contains an extensive network of nerve cells that detect and relay changes in the environment. There are separate receptors for heat, cold, touch, and pain. Damage to these nerve cells is known as neuropathy, which results in a loss of sensation in the affected areas. Patients with neuropathy may not feel pain when they suffer injury, increasing the risk of severe wounding or the worsening of an existing wound. 
Increasing exposure of the skin to damaging environmental influences such as ultraviolet radiation, climatic determinants, chemicals or infections, resulting in numerous skin diseases. Skin aging and skin carcinogenesis are caused by both genetic and environmental factors. And also in diseases like psoriasis, atopic dermatitis and collagen diseases, genetic, immunologic and environmental factors interact. Allergies, irritants, genetic makeup, certain diseases, and immune system problems – all can cause skin conditions. 
Publications and factsheets
American Academy of Dermatology Association 
Skin Diseases 
Common skin conditions 
List of skin conditions 
- www.clinimed.co.uk | structure and function of the skin
- www.aad.org | diseases
- www.niams.nih.gov | skin diseases
- www.nhs.uk | common skin conditions
- en.wikipedia.org | List of skin conditions
- icd.who.int | 10/2016
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