Metabolism is a set of chemical reactions that occur in a living organism to sustain life. These processes allow organisms to grow and reproduce, maintain their structures and respond to environmental impacts.

Metabolism is usually divided into 2 stages:

               •         catabolism — complex organic substances break down to simpler ones, usually releasing  energy

               •         anabolism — more complex substances are formed from simpler ones, this is  accompanied by energy expenditures [1].

Lipids are fats that are synthesized in the liver or enter the body through food. In addition to the energy function, fats are important components of cell membranes, are involved in the synthesis of hormones, the transmission of nerve impulses, and perform a lot of other vital tasks. All fats are hydrophobic and most of them are insoluble in blood, therefore lipid metabolism is a rather complex physicochemical process of the body [2].

Lipid metabolism disorders affect the processes of absorption, transformation and metabolism of fats in the body. Therefore, it significantly affects the state of the whole organism and can lead to the development of severe consequences.

Factors that accompany the development of lipid metabolism disorders:

               •         inherited from one or both parents of an abnormal gene responsible for the synthesis of  cholesterol [3]

               •         sedentary lifestyle

               •         diabetes mellitus [4]

               •         taking excess alcohol

               •         obstructive liver disease

               •         chronic kidney disease

               •         hypothyroidism [5]

               •         medications or their combinations

Disorders of lipid metabolism is one of the main causes of atherosclerosis, obesity, nervous system depletion and sexual dysfunctionIt also causes:

               •         deficiency of pancreatic lipase [6]

               •         insufficient production of bile

               •         disruption of the thyroid gland, reproductive system, pituitary gland

               •         failure of the hypothalamus [7]

               •         negative changes in the function of the nervous system

               •         ketosis associated with increased formation of ketone bodies [8]

               •         disorder of the intestinal epithelium

               •         exposure to ionizing radiation [9]

               •         various diseases, such as jaundice, inflammation of the pancreas, hepatosis, Whipple's,  and others [10].

Undoubtedly, each of us has faced health problems in his life, in which it is necessary not only to carry out treatment, but also subsequently to prevent possible relapses of diseases and disorders. It is known what dangerous consequences entail disturbances in lipid metabolism, and the best solution is to influence directly the root cause.

According to research, one of the best ways to prevent the development of pathological processes in the body is curcumin [11].

Curcumin is the main curcuminoid [12] found in turmeric root [13].

Curcumin is one of the most widely tested natural compounds. One of the detrimental effects of increased total body fat is the presence of chronic inflammation of low severity, which leads to metabolic syndrome and related diseases. Laboratory studies have shown that curcumin is the main metabolite found in plasma, thereby reducing body mass index, hemoglobin, glucose, triglyceride [14] levels, enhances metabolic processes in the body, improve insulin sensitivity, regulates the death of adipocytes [15], suppresses enzymes that have fundamental functions in the mechanism of obesity development. All these make curcumin therapeutically a useful tool for preventing or correcting fat metabolism disorders in the body and diseases caused by this disorder [16] [17] [18] [19] [20] [21] [22].

In addition, in laboratory conditions, curcumin has demonstrated multiple pharmacological properties, including antioxidant, anti-inflammatory, anticarcinogenic, cardioprotective, hepatoprotective, antidepressant, immune-strengthening and many others [23].

Unfortunately, these encouraging initial findings were not supported in during clinical trials in humans due to the very low bioavailability of curcumin, which averaged no more than 0.1% [24]. This low bioavailability does not allow curcumin to show its therapeutic potential when taken as a powder or extract.

It is worth noting that laboratory studies with curcumin have greatly increased interest in it all over the world, and especially it was shown in the segment biologically active additives. On almost every supplement site, you can purchase preparations made from powder or turmeric extract and find information about the pharmacological effect of curcumin on dozens of diseases. This method of presenting information is a substitution of concepts when laboratory findings are issued as clinical results. Neither turmeric extract, nor even powder, nor even powder, is able to exert the pharmacological effect that curcumin has shown in laboratory studies. Increasing the bioavailability of curcumin has been the topic of many research teams for several decades [25]. Currently, several technologies have already been developed to increase the bioavailability of curcumin. The most advanced technology for the delivery of active substances into the blood is liposomal [26].

Liposomal technology of curcumin delivery allows to achieve the desired pharmacological effect in humans and animals, which has been demonstrated in thousands of laboratory studies [27] [28].

References:

1             https://en.wikipedia.org/wiki/Metabolism

2             https://en.wikipedia.org/wiki/Lipid

3             https://en.wikipedia.org/wiki/Cholesterol

4             https://en.wikipedia.org/wiki/Diabetes

5             https://en.wikipedia.org/wiki/Hypothyroidism

6             https://en.wikipedia.org/wiki/Pancreatic_enzymes_(medication)

7             https://en.wikipedia.org/wiki/Hypothalamus

8             https://en.wikipedia.org/wiki/Ketosis

9             https://en.wikipedia.org/wiki/Ionizing_radiation

10           https://www.researchgate.net/publication/268924446_Disorders_of_Lipid_Metabolism

11           https://en.wikipedia.org/wiki/Curcumin

12           https://en.wikipedia.org/wiki/Curcuminoid

13           https://en.wikipedia.org/wiki/Turmeric

14           https://en.wikipedia.org/wiki/Triglyceride

15           https://en.wikipedia.org/wiki/Adipocyte

16           https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6582779/

17           https://www.hindawi.com/journals/omcl/2020/1520747/

18           https://www.mdpi.com/2072-6643/12/1/118/htm

19           https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5336246/

20           https://www.sciencedirect.com/science/article/pii/S2213422018301069

21           https://bmcgastroenterol.biomedcentral.com/articles/10.1186/s12876-019-1055-4

22           https://bmcnephrol.biomedcentral.com/articles/10.1186/s12882-019-1621-6

23           https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5664031/

24           https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6770259/

25           https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3918523/

26           https://en.wikipedia.org/wiki/Liposome

27           https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3519006/

28           https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5557698/

SUPREME PHARMATECH CO., LTD. SUPREME PHARMATECH CO., LTD. 399/90-95 Moo 13 Kingkaew Rd. Soi 25/1, T. Rachateva, A. Bangplee, Samutprakan 10540, THAILAND E-Mail : mail.suprempharmatech@gmail.com ID Line : supremepharmatech Hotline : 0888 700-007 Tel. +66-2-1307888
Fax +66-2-1307889